What is 1,4-Butanediol CAS 110-63-4 ?

  • 1,4-Butanediol, with the chemical formula C4H10O2 and CAS number 110-63-4, is a colorless, viscous liquid organic compound belonging to the class of diols, or aliphatic glycols. It is a versatile chemical with a wide range of applications across various industries. In this comprehensive explanation, I will delve into its chemical properties, synthesis methods, applications, safety considerations, and environmental impact.

Chemical Properties:

1,4-Butanediol is characterized by its linear molecular structure, consisting of four carbon atoms and two hydroxyl (OH) groups attached to adjacent carbon atoms. This arrangement imparts unique properties to the compound, including its ability to dissolve both polar and non-polar substances. Additionally, it has a relatively low freezing point and a boiling point of 230°C, making it a valuable component in various chemical processes and formulations.


There are several methods to synthesize 1,4-butanediol, the most common of which is the Reppe process. This method involves the reaction of acetylene and formaldehyde in the presence of a catalyst to form vinyl acetaldehyde. The vinyl acetaldehyde is then hydrogenated to produce 1,4-butanediol. Other synthesis routes include the use of maleic anhydride and tetrahydrofuran as starting materials.


1,4-Butanediol finds applications in diverse industries due to its chemical properties. One of its primary uses is as a precursor in the production of polyurethanes, which are widely used in foams, coatings, adhesives, and elastomers. Additionally, it serves as a solvent in various industrial processes, including the manufacturing of plastics, resins, and pharmaceuticals.

In the automotive industry, 1,4-butanediol is utilized as a key component in the production of brake fluids. It also finds application as a humectant in cosmetics and personal care products, helping to retain moisture and improve product texture.

Safety Considerations:

While 1,4-butanediol has numerous applications, it is essential to recognize potential safety hazards associated with its handling and use. The compound can be harmful if ingested, inhaled, or absorbed through the skin. Direct contact with the liquid may cause skin and eye irritation. Moreover, the vapor of 1,4-butanediol is flammable, and proper precautions must be taken during storage and transportation.

Due to its potential for abuse and illegal use, it is crucial to acknowledge that 1,4-butanediol can be converted into gamma-hydroxybutyrate (GHB) in the body. GHB is a central nervous system depressant, and its use as a recreational drug poses severe health risks, including respiratory depression, unconsciousness, and even death. Therefore, regulatory measures and public awareness campaigns are necessary to address this issue.

Environmental Impact:

Concerns about environmental impact surround the production and disposal of 1,4-butanediol. The Reppe process for synthesizing 1,4-butanediol involves the use of catalysts and may generate by-products and waste, potentially leading to environmental pollution. Proper waste management and treatment are essential to minimize its impact on ecosystems and human health.


1,4-butanediol is a versatile compound with significant applications across various industries. Its chemical properties and synthesis methods make it valuable for the production of polyurethanes, plastics, and pharmaceuticals. However, its potential for abuse as a precursor to GHB requires stringent regulations and public awareness campaigns to ensure safety. Additionally, environmental considerations call for responsible waste management practices in its production and use. By understanding the compound’s characteristics and risks, we can harness its benefits while minimizing its negative impact on society and the environment.

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